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UID:20250817T233019EDT-5810gUMVr5@132.216.98.100
DTSTAMP:20250818T033019Z
DESCRIPTION:Stephen J. Weiss\, MD\n\nUniversity of Michigan\n\nMetastasizin
 g breast carcinoma cells are believed to mobilize proteolytic systems simi
 lar\, if not identical\, to those employed by normal mammary epithelial ce
 lls undergoing branching morphogenesis. However\, the key molecular effect
 ors underlying mammary gland morphogenesis have not been identified\, nor 
 has their role in breast cancer invasion in vivo been established. In rece
 nt studies\, we find that the membrane-anchored matrix metalloproteinase\,
  MT1-MMP/MMP14\, but not the closely related metalloproteinase\, MT2-MMP/M
 MP15\, serves as the dominant proteolytic effector of both mammary gland b
 ranching morphogenesis and breast carcinoma cell invasion in vivo. Unexpec
 tedly\, while epithelial cell-specific targeting of MT1-MMP in normal epit
 helial cells fails to impair branching\, deleting the proteinase in carcin
 oma cells abrogates invasion and metastasis. By contrast\, deleting MT1-MM
 P expression from the periductal stroma ablates mammary gland morphogenesi
 s without affecting cancer cell invasion. Together\, these data uncover ov
 erlapping\, but divergent matrix remodeling strategies that underlie mamma
 ry gland morphogenesis and breast cancer progression.\n
DTSTART:20180314T153000Z
DTEND:20180314T163000Z
LOCATION:Room 2/45\, Strathcona Anatomy and Dentistry Building\, CA\, QC\, 
 Montreal\, H3A 0C7\, 3640 rue University
SUMMARY:Dr. Stephen Weiss: Divergent Tissue-Remodeling Strategies Define Ep
 ithelial Cell Branching Morphogenesis and Neoplastic Invasion Programs
URL:/anatomy/channels/event/dr-stephen-weiss-divergent
 -tissue-remodeling-strategies-define-epithelial-cell-branching-285672
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