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UID:20250807T163804EDT-4242u23iv9@132.216.98.100
DTSTAMP:20250807T203804Z
DESCRIPTION: \n\nDr. Ajitha Thanabalasuriar\n\nAssistant Professor\, CRC Ti
 er 2 Infection\, Immunity\, and Targeted Drug Therapies\, ºÚÁϲ»´òìÈ Universit
 y\, Department of Pharmacology and Therapeutics\n\n \n\nTalk title: ‘‘Alve
 olar Macrophages: moving to maintain lung homeostasis’’\n\n \n\nDuring res
 piration\, humans breathe in more than 10\,000 liters of non-sterile air d
 aily\, allowing some pathogens access to alveoli. Interestingly\, alveoli 
 outnumber alveolar macrophages (AMs)\, which favors alveoli devoid of AMs.
  If AMs\, like most tissue macrophages\, are sessile\, then this numerical
  advantage would be exploited by pathogens unless neutrophils from the blo
 od stream intervened. However\, this would translate to omnipresent persis
 tent inflammation. Developing in vivo real-time intravital imaging of alve
 oli revealed AMs crawling in and between alveoli using the pores of Kohn. 
 Importantly\, these macrophages sensed\, chemotaxed\, and\, with high effi
 ciency\, phagocytosed inhaled bacterial pathogens such as P. aeruginosa an
 d S. aureus\, cloaking the bacteria from neutrophils. Impairing AM chemota
 xis toward bacteria induced superfluous neutrophil recruitment\, leading t
 o inappropriate inflammation and injury.\n\n \n\nThis seminar will be give
 n online via Zoom. Details in attached poster.\n
DTSTART:20220505T200000Z
DTEND:20220505T210000Z
SUMMARY:CFTRc seminar - Dr. Ajitha Thanabalasuriar
URL:/cftrc/channels/event/cftrc-seminar-dr-ajitha-than
 abalasuriar-339450
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