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DESCRIPTION:Register here.\n\nStream via vimeo here.\n\nAna Luisa Pinho\n\n
 BrainsCAN Postdoctoral Fellow\, Western University\, Canada\n\nAbstract: F
 unctional Magnetic Resonance Imaging (fMRI) provides means to characterize
  brain activations in response to behavior. However\, cognitive neuroscien
 ce has been limited to group-level effects referring to the performance of
  specific tasks. To obtain the functional profile of elementary cognitive 
 mechanisms\, the combination of brain responses to many tasks is required\
 , by pooling data or results from different single-task studies. Meta-anal
 yses allow the accumulation of knowledge across studies. Yet\, they are ty
 pically impacted not only by inter-subject and inter-site variability but 
 also loss of information from sparse peak-coordinate representations. In t
 his talk\, I will address a battery of studies\, which combine deep phenot
 yping and multitask-fMRI approaches to extensively investigate the functio
 nal signatures of the different components that characterize the human beh
 avior. First\, I will describe a set of experiments\, based on temporally 
 controlled task designs\, reported in [1]\, [2] and [3]\, in which we leve
 rage a collection of source task-fMRI data from the Individual Brain Chart
 ing (IBC) dataset. The main goal herein is to investigate the feasibility 
 of performing individual functional brain atlasing\, free from inter-subje
 ct and inter-site variability\, as an effort to establish an univocal rela
 tionship between functional segregation of brain regions and elementary me
 ntal functions. Results show that individual topographies---common to all 
 tasks---are consistently mapped within and\, to a lesser extent\, across p
 articipants. Besides\, prediction scores associated with the reconstructio
 n of contrasts of one task from the remaining ones reveal the quantitative
  contribution of each task to these common representations. Yet\, scores d
 ecreased when subjects were permuted between train and test\, confirming t
 hat topographies are driven by subject-specific variability. In addition\,
  we demonstrate how cognitive mapping can benefit from contrasts accumulat
 ion\, by analyzing the functional fingerprints of a set of individualized 
 regions-of-interest from the language network. Second\, I will describe ou
 r ongoing work on the quality-assessment and validation of a subset of tas
 ks from the IBC dataset based on naturalistic stimuli using two types of e
 ncoding models: the unsupervised Fast Shared Response Model [4]\, and a fe
 ature-defined model based on Deep Convolutional Neural Networks [5\, 6]. 
 \n\nBio: Ana Luísa Pinho graduated in Engineering Physics at Instituto Sup
 erior Técnico (University of Lisbon\, Lisbon\, Portugal). During her docto
 ral studies at Karolinska Institutet (Stockholm\, Sweden)\, she studied th
 e neurocognitive mechanisms implicated in musical creativity through fMRI.
  Afterwards\, she worked as a Postdoctoral Researcher at NeuroSpin (Paris\
 , France) on dataset development and brain atlasing using neuroimaging dat
 a\; she was directly involved in the Individual Brain Charting project\, a
  collaborative ten-years consortium under the Human Brain Project flagship
 . She is now a BrainsCAN Postdoctoral Fellow at Western University (London
  ON\, Canada) working on the characterization of the cortico-basal ganglia
 -cerebellar circuitry involved in the ability to form temporal predictions
  during rhythmic and non-rhythmic sequences of events. To this end\, she i
 s leveraging a cognitive-specific battery of task-fMRI data and applying a
 tlasing techniques as means to identify functional specialization and conn
 ectivity in this cortical-subcortical network.\n\nThe Feindel Brain and Mi
 nd Seminar Series will advance the vision of Dr. William Feindel (1918–201
 4)\, Former Director of the Neuro (1972–1984)\, to constantly bridge the c
 linical and research realms. The talks will highlight the latest advances 
 and discoveries in neuropsychology\, cognitive neuroscience\, and neuroima
 ging.\n\nSpeakers will include scientists from across The Neuro\, as well 
 as colleagues and collaborators locally and from around the world. The ser
 ies is intended to provide a virtual forum for scientists and trainees to 
 continue to foster interdisciplinary exchanges on the mechanisms\, diagnos
 is and treatment of brain and cognitive disorders.\n\n \n
DTSTART:20230322T190000Z
DTEND:20230322T200000Z
LOCATION:Jeanne Timmins Amphitheatre\, Montreal Neurological Institute\, CA
 \, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Feindel Brain and Mind Seminar Series: Deep behavioral phenotyping 
 in functional MRI for cognitive mapping of the human brain
URL:/channels/channels/event/feindel-brain-and-mind-se
 minar-series-deep-behavioral-phenotyping-functional-mri-cognitive-mapping-
 346381
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