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UID:20250731T225921EDT-1396cOuPDZ@132.216.98.100
DTSTAMP:20250801T025921Z
DESCRIPTION:Abstract:\n\nCombining functionalization at a distant position 
 from a reactive site with the creation of several consecutive stereogenic 
 centers\, including the formation of a quaternary carbon stereocenter\, in
  acyclic system represents a pinnacle in organic synthesis. Here we report
  the regioselective Heck arylation of terminal olefins as a distant trigge
 r for the ring-opening of cyclopropanes. This Pd-catalyzed unfolding of st
 rained cycle\, driving force of the chain-walking process\, remarkably pro
 ved its efficiency and versatility\, as the reaction proceeded regardless 
 of the molecular distance between the initiation (double bond) and termina
 tion (alcohol) sites. Moreover\, employing stereodefined polysubstituted c
 yclopropane vaults allowed to access sophisticated stereoenriched acyclic 
 scaffolds in good yields. Conceptually\, we demonstrated that merging cata
 lytically a chain walking process with a selective C–C bond cleavage repre
 sents a powerful approach to construct linear skeleton possessing several 
 stereogenic centers.\n\nBio:\n\nIlan Marek is Professor at the Schulich Fa
 culty of Chemistry at the Technion – Israel Institute of Technology. Since
  2005\, he holds the Sir Michael and Lady Sobell Academic Chair\, is a mem
 ber of the French Academy of Sciences and a member of the Israel Academy o
 f Sciences and Humanities. He was educated in France\, received his PhD th
 esis in 1988 from the University Pierre et Marie Curie\, Paris\, (France) 
 with Prof. Jean F. Normant. After a one-year period as a postdoctoral fell
 ow in Louvain-la-Neuve (Belgium) with Prof. Leon Ghosez\, he obtained a re
 search position at the CNRS (Centre National de la recherche Scientifique)
  at the University Pierre et Marie Curie in France in 1990. After obtainin
 g his Habilitation in Organic Chemistry\, he moved to the Technion-Israel 
 Institute of Technology in 1997. Prof. Marek has received several awards a
 nd recognitions for his research and teaching.\n
DTSTART:20191010T170000Z
DTEND:20191010T183000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Ilan Marek - Remote Functionalization
URL:/chemistry/channels/event/chemical-society-seminar
 -ilan-marek-remote-functionalization-300799
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