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UID:20250731T063209EDT-0882kWlO8P@132.216.98.100
DTSTAMP:20250731T103209Z
DESCRIPTION:Zoom Link: https://mcgill.zoom.us/j/84811396167\n\nAbstract:\n
 \nFunctional compartmentalization is a ubiquitous hallmark of life\; by se
 gregating bio-molecules and their interactions cells achieve specializatio
 n and improved efficiency of many of their functions. In eukaryotic cells\
 , the genetic material is known to be separated from the cytoplasm by the 
 nuclear membrane within the few cubic micrometers of nuclear space. Recent
  experiments have revealed the ubiquitous presence of compartmentalization
  occurring at multiple scales in the nucleoplasmic environment. The drivin
 g force for these compartmentalization appears to be a juxtaposition of pr
 otein-nucleic acids phase-separation and active non-equilibrium processes.
  Due to the multi-scale and multi-component nature of the problem mechanis
 tic understanding of how the interplay of thermodynamic and kinetic proces
 ses shapes the intranuclear order is lacking. During the talk\, a selectio
 n of recent studies will be presented showcasing how our group uses comput
 er simulations for probing phase-separation phenomena in cell nuclei using
  multi-scale physics-based models.\n\nBio:\n\nProfessor Potoyan received h
 is Ph.D. in Chemical Physics at the University of Maryland-College Park in
  2012. He spent the next few years training as a postdoctoral fellow in th
 e Center for Theoretical Biological Physics at Rice University. He joined 
 Iowa State in 2017 as a Caldwell Assistant Professor of Chemistry and curr
 ently holds a courtesy faculty appointment in BBMB as well as in BCB progr
 ams. The research field of Professor Potoyan is in computational biophysic
 s broadly defined. His group is using multi-scale computational tools root
 ed in statistical physics\, machine learning\, and data analytics to work 
 on a variety of biologically motivated problems. Some of the active areas 
 of research in the group include the condensation of disordered proteins a
 nd nucleic acids\,  enzyme dynamics\, chromatin organization\, and epigene
 tic networks of stem cells.  \n
DTSTART:20201110T180000Z
DTEND:20201110T193000Z
SUMMARY:Chemical Society Seminar: Davit Potoyan - Multi-scale computational
  studies of assembly\, regulation\, and phase separation in the cell nucle
 us.
URL:/chemistry/channels/event/chemical-society-seminar
 -davit-potoyan-multi-scale-computational-studies-assembly-regulation-and-3
 25008
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