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UID:20250731T214829EDT-5926aJKurk@132.216.98.100
DTSTAMP:20250801T014829Z
DESCRIPTION:The lecture will give an overview on trifluoromethylation react
 ions carried out with hypervalent iodine reagents of type 1 and 2 [1]. The
 se transformations\, upon which an intact CF3 group may be transferred to 
 a large variety of substrates\, are catalyzed or assisted by Brønsted and 
 Lewis acids\, or by a number of transition-metal complexes. N- and P-trifl
 uoromethylations of benzimidazole or both primary and secondary phosphines
 \, respectively\, are used for the preparation of corresponding carbene li
 gands [2] and novel Pstereogenic phosphines [3] for applications in homoge
 neous catalysis. Thus\, Grubbs-II-type complexes 3 provide high selectivit
 ies in e.g. ethenolysis reactions while ligand 4 affords enantioselectivit
 ies in the Ir-catalyzed hydrogenation of cyclic iminium salts that are hig
 her than with the parent ligand. Structural modifications [4] and modes of
  activation of the reagents as well as mechanistic insight deriving from b
 oth experiments and quantumchemical calculations [5] will also be presente
 d.\n\n\n	References\n\n[1] For a comprehensive review\, see (a) J. Charpent
 ier\, N. Früh\, A. Togni\, Chem. Rev. 2015\, 115\, 650\, and references ci
 ted therein.\n	[2] (a) P.S. Engl\, R. Senn\, E. Otth\, A. Togni\, Organomet
 allics 2015\, 34\, 1384. (b) P.S. Engl\, A. Fedorov\, C. Copéret\, A. Togn
 i\, Organometallics 2016\, 35\, 887.\n	[3] R. Schwenk\, A. Togni\, Dalton T
 rans. 2015\, 44\, 19566.\n	[4] V. Matousek\, J. Vaklavik\, P. Hajek\, J. Ch
 arpentier\, Z.E. Blastik\, E. Pietrasiak\, A. Budinska\, A. Togni\, P. Bei
 er\, Chem. Eur. J. 2016\, 22\, 417.\n	[5] (a) O. Sala\, H. P. Lüthi\, A. To
 gni\, M. Iannuzzi\, J. Hutter\, J. Comput. Chem. 2015\, 36\, 785. (b) O. S
 ala\, N. Santschi\, S. Jungen\, H.P. Lüthi\, M. Iannuzzi\, N. Hauser\, A. 
 Togni\,\n	Chem. Eur. J. 2016\, 22\, 1704.\n
DTSTART:20161025T170000Z
DTEND:20161025T183000Z
LOCATION:Rm 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\, 
 801 rue Sherbrooke Ouest
SUMMARY:CCVC Seminar: Dr. Antonio Togni - The Trifluoromethyl Group in Cata
 lysis and Organometallic Chemistry
URL:/chemistry/channels/event/ccvc-seminar-dr-antonio-
 togni-trifluoromethyl-group-catalysis-and-organometallic-chemistry-261963
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