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UID:20250731T214850EDT-5707s9BpBM@132.216.98.100
DTSTAMP:20250801T014850Z
DESCRIPTION:Multidrug resistance infections are putting us at risk of enter
 ing into a ‘postantibiotic era’ with people at the mercy of microbes and t
 reatments like major surgery no longer possible. New approaches and signif
 icant efforts must be focused on developing new antibiotics. Our research 
 aims to understand the structure and function of new antimicrobial targets
 \, developing them into tangible enzymes for intervention with new antibio
 tics. Current work focuses on the assembly process of the ribosome\; a pat
 hway of tremendous potential but that has not been explored as a target fo
 r antimicrobials yet. Cryo-electron microscopy (cryo-EM) had played a cent
 ral role in the study of ribosome structure since the  development of this
  technique in the mid 1980s. Until recently cryo-EM structures were limite
 d to ~10Å in the best cases. However\, the recent\n	advent of direct electr
 on detectors has greatly improved the resolution of cryo-EM structures to 
 the point where atomic resolution is now achievable. This improved resolut
 ion is allowing cryo-EM to make groundbreaking contributions in essential 
 aspects of ribosome biology\, including the assembly process. In my talk\,
  I will summarize important insights that cryo-EM\, in combination with ch
 emical and genetic approaches\, has already brought to our current underst
 anding of the ribosomal assembly process in bacteria using previous detect
 or technology.\n	More importantly\, I will discuss how the higher resolutio
 n structures now attainable with direct electron detectors can be leverage
 d to propose precise testable models regarding this process. These structu
 res are providing an effective platform to develop new antibiotics that ta
 rget this fundamental cellular process.\n
DTSTART:20170328T170000Z
DTEND:20170328T181500Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Dr. Joaquin Ortega - The Impact of Recent
  Improvements in Cryo-electron Microscopy Technology on the Understanding 
 New Antimicrobial Targets
URL:/chemistry/channels/event/chemical-society-seminar
 -dr-joaquin-ortega-impact-recent-improvements-cryo-electron-microscopy-265
 640
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