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UID:20250707T071644EDT-7603zDzGVG@132.216.98.100
DTSTAMP:20250707T111644Z
DESCRIPTION:Jack Kalbfleisch\, PhD\n\nDepartment of Biostatistics\, Univers
 ity of Michigan\, Ann Arbor\n\nMatch making in a Kidney Paired Donation Pr
 ogram\n\nALL ARE WELCOME\n\nAbstract:\n\nA kidney-paired donation (KPD) po
 ol consists of transplant candidates and their incompatible donors\, along
  with non-directed donors (NDDs). A computer algorithm makes use of inform
 ation on blood type of candidates and donors as well as donor HLA antigens
  and candidate sensitivities to predict possible matches.  In a match run\
 , exchanges are arranged among pairs in the pool via cycles\, as well as c
 hains created from NDDs. A problem of importance is how to arrange cycles 
 and chains to optimize the number of transplants. I will discuss various s
 chemes for carrying out match runs and compare them in examples and in sim
 ulations.  Our proposed approach takes account of probabilities that chose
 n transplants may not be completed as well as allowing for contingencies w
 hen proposed transplants turn out not to be viable. We propose an approach
  based on selection of locally relevant subsets with respect to cycles and
  chains of a given size. Simulations are considered that utilize data on c
 andidate/donor pairs and NDDs from the Alliance for Paired Donation. Incor
 porating uncertainties and fallbacks into the selection process yields sub
 stantially more transplants on average\, increasing the number of transpla
 nts by as much as 40% compared to a standard selection scheme.\n\nBio:\n\n
 Dr. Kalbfleisch is a professor of biostatistics and statistics at the Univ
 ersity of Michigan. He served as chair of the Department of Biostatistics 
 from 2002 to 2007 and as Director of the Kidney Epidemiology and Cost Cent
 er from 2008 to 2011. He received his Ph.D. in statistics in 1969 from the
  University of Waterloo. He was an assistant professor of statistics at th
 e State University of New York at Buffalo (1970-73) and on faculty at the 
 University of Waterloo (1973-2002). At Waterloo\, he served as chair of th
 e Department of Statistics and Actuarial Science (1984-1990) and as dean o
 f the faculty of Mathematics (1990-1998). He has held visiting appointment
 s as Professor at the University of Washington\, the University of Califor
 nia at San Francisco\, the University of Auckland\, Fred Hutchinson Cancer
  Research Center and the National University of Singapore. He has interest
 s in and has publised in various areas of statistics and biostatistics inc
 luding life history and survival analysis\, likelihood methods of inferenc
 e\, bootstrapping and estimating equations\, mixture and mixed effects mod
 els and medical applications\, particularly in the area of renal disease a
 nd organ transplantation. Dr. Kalbfleisch is a Fellow of the American Stat
 istical Association and the Institute of Mathematical Statistics. He is al
 so an elected member of the International Statistical Institute\, a Fellow
  of the Royal Society of Canada and a Gold Medalist of the Statistical Soc
 iety of Canada. He also received the Distinguished Research Award from the
  UM School of Public Health in 2011.\n\n \n
DTSTART:20160329T193000Z
DTEND:20160329T203000Z
LOCATION:Room 24\, Purvis Hall\, CA\, QC\, Montreal\, H3A 1A2\, 1020 avenue
  des Pins Ouest
SUMMARY:Biostatistics Seminar: 'Match making in a Kidney Paired Donation Pr
 ogram'
URL:/epi-biostat-occh/channels/event/biostatistics-sem
 inar-match-making-kidney-paired-donation-program-259862
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