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UID:20250801T151840EDT-0188zsPOS8@132.216.98.100
DTSTAMP:20250801T191840Z
DESCRIPTION:PhD Defense of Juliane Wunderlich\, Institute of Parasitology\n
 Malaria is one of the most severe public health problems worldwide and a l
 eading cause of death and disease in developing countries. The alarming sp
 read of resistance to first-line as well as second- and third-line antimal
 arials accentuates the need for the better biochemical and physiological u
 nderstanding of the interaction of malaria parasites with these drugs to d
 evelop novel therapeutic strategies that either inhibit or circumvent resi
 stance mechanisms.\nThe digestive vacuole (DV) of Plasmodium falciparum is
  the site of action of many antimalarials and plays a pivotal role in drug
  resistance. Its membrane is thought to contain pumps and transporters tha
 t are implicated in the maintenance of the acidic pH in the DV lumen (pHDV
 ) and the transport of antimalarials. The low pHDV is important for the fu
 nctions of this compartment\, including hemoglobin degradation and heme de
 toxification. A possible alteration of pHDV in response to quinoline-conta
 ining antimalarials (QCAs) has remained controversial due to the lack of a
 ccurate measurements and the mechanisms of action of these drugs are still
  unclear.\nEveryone in the ºÚÁϲ»´òìÈ community is welcome to attend a PhD ora
 l defense. Please join us in celebrating the accomplishments of our PhD ca
 ndidates.\n
DTSTART:20150910T130000Z
DTEND:20150910T130000Z
LOCATION:MS2-022 (Faculty Lounge)\, Macdonald-Stewart Building\, CA\, QC\, 
 St Anne de Bellevue\, H9X 3V9\, 21111 Lakeshore Road
SUMMARY:PhD Oral Defense: the effect of antimalarial drugs on intracellular
  pH in Plasmodium falciparum
URL:/macdonald/channels/event/phd-oral-defense-effect-
 antimalarial-drugs-intracellular-ph-plasmodium-falciparum-254903
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