BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20250725T064207EDT-9015SVdRJU@132.216.98.100
DTSTAMP:20250725T104207Z
DESCRIPTION: \n\nPhD Oral Defense of Rodrigo Camponogara Bohrer\, Departmen
 t of Animal Science\n\nDNA DSBs are the most important type of DNA damage 
 because their defective repair can induce genome instability\, deleterious
  mutations and cellular death. Studies\, most using mice and humans\, have
  shown that DNA DSBs is an important component affecting early embryo deve
 lopment and somatic cell reprogramming during the production of iPS cells.
  However\, the occurrence and effects of DNA DSBs\, and the mechanism invo
 lved in DNA DSBs repair have not been systematically investigated during e
 arly embryo development and cell reprogramming in embryos produced by soma
 tic cell nuclear transfer (SCNT). Therefore\, in the first manuscript of t
 his thesis\, we characterized the occurrence of DNA DSBs during early deve
 lopment of IVF and SCNT porcine embryos. ... In the second manuscript of t
 his thesis\, we investigated the effect of HDACi treatment on DNA DSBs rep
 air and development of SCNT embryos.  ... In the third manuscript\, we com
 pared the occurrence of DSBs between early- and late-cleaving embryos. Our
  results showed that the presence of DNA DSBs affects the cleavage kinetic
 s and embryo developmental capacity to the blastocyst stage. Finally\, in 
 the fourth manuscript of this thesis\, we assessed the importance of the H
 R and the NHEJ pathways for DNA DSBs repair during early embryo developmen
 t.\n\nEveryone in the ºÚÁϲ»´òìÈ community is welcome to attend a PhD oral def
 ense. Please join us in celebrating the accomplishments of our PhD candida
 tes.\n\n \n\n \n
DTSTART:20160826T171500Z
DTEND:20160826T171500Z
LOCATION:MS2-022 (Faculty Lounge)\, Macdonald-Stewart Building\, CA\, QC\, 
 St Anne de Bellevue\, H9X 3V9\, 21111 Lakeshore Road
SUMMARY:PhD Oral Defense: DNA double-strand breaks in early developing embr
 yos: occurrence\, consequences and regulation of repair mechanisms
URL:/macdonald/channels/event/phd-oral-defense-dna-dou
 ble-strand-breaks-early-developing-embryos-occurrence-consequences-and-262
 374
END:VEVENT
END:VCALENDAR