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UID:20250813T192718EDT-8749joH65F@132.216.98.100
DTSTAMP:20250813T232718Z
DESCRIPTION:NRS kicks off its Environmental Biology Seminar Series with an 
 online seminar by Ana Jimenez\, Assistant Professor\, Colgate University.
 \n\nSeminars will be held from 11:30-12:30 (unless otherwise indicated)\, 
 with a round table discussion from 2:00-3:00 EST.  Zoom links will be prov
 ided in an email announcement.\n\nAcross Mammalia\, body size and lifespan
  are positively correlated. A mouse has a significantly shorter lifespan t
 han an elephant. However\, in dogs\, the opposite is true: small dogs have
  longer lives compared with large dogs. Dr. Jimenez will present data acro
 ss levels of organization to tease apart life-history traits that may affe
 ct dog lifespan\, including adaptations at the whole-organism\, and organ-
 level. This talk will also explore cellular mechanisms that may allow for 
 small breeds to age more slowly compared with large breeds in the context 
 of cellular metabolism and oxidative stress. Additionally\, we will explor
 e ways to alter cellular phenotypes in small and large breed dogs by alter
 ing cellular architecture to test the “membrane pacemaker” hypotheses of m
 etabolism and aging. This hypothesis suggests that increased lipid unsatur
 ation and large amounts of polyunsaturated fatty acids (PUFAs) in cell mem
 branes increases cellular metabolic rate and increases the vulnerability o
 f the cell to oxidative damage\, thus increasing organismal metabolic rate
  and decreasing longevity.\n\nABOUT THE SPEAKER\n\nDr. Ana Jimenez’s love 
 for animals has always been evident\, as she has always shared her life wi
 th dogs and cats. Her research has included animalsfrom fish and crustacea
 ns\, to multitude of birds species to now dogs. Her background in biochemi
 stry and physiology allows her to ask question across levels of organizati
 on from the whole-organism to their cells. In her free time\, Dr. Jimenez 
 spends time hiking with her two dogs\, Emma and Rayne.\n
DTSTART:20200910T153000Z
DTEND:20200910T163000Z
LOCATION:Online on Zoom
SUMMARY:Why do large breed dogs 'die young'? Metabolic consequences of agin
 g in small and large breed dogs
URL:/macdonald/channels/event/why-do-large-breed-dogs-
 die-young-metabolic-consequences-aging-small-and-large-breed-dogs-324068
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