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DESCRIPTION: \n\n\n\nTITLE / TITRE\n\nA Generalized Logrank-type Test for C
 omparison of Treatment Regimes in Sequential Multiple Assignment Randomize
 d Trials\n	 \n\nABSTRACT / RÉSUMÉ\n\nThe sequential multiple assignment ran
 domized trial (SMART) is the gold standard study design for the evaluation
  of multistage treatment regimes\, which comprise sequential decision rule
 s that recommend treatments for a patient at each of a series of decision 
 points based on their evolving characteristics. A common goal is to compar
 e the set of so-called embedded regimes represented in the design on the b
 asis of a primary outcome of interest. In the study of chronic diseases an
 d disorders\, this outcome is often a time to an event\, and a goal is to 
 compare the distributions of the time-to-event outcome associated with eac
 h regime in the set. We present a general statistical framework in which w
 e develop a logrank-type test for comparison of the survival distributions
  associated with regimes within a specified set based on the data from a S
 MART with an arbitrary number of stages that allows incorporation of covar
 iate information to enhance efficiency and can also be used with data from
  an observational study. The framework provides clarification of the assum
 ptions required to yield a principled test procedure\, and the proposed te
 st subsumes or offers an improved alternative to existing methods. The met
 hods are applied to a SMART in patients with acute promyelocytic leukemia.
 \n\nLaunch Meeting - Zoom\n\n \n\n \n
DTSTART:20250124T203000Z
DTEND:20250124T213000Z
SUMMARY:Marie Davidian (North Carolina State University)
URL:/mathstat/channels/event/marie-davidian-north-caro
 lina-state-university-362735
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