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UID:20250803T085535EDT-8190Vcuiwb@132.216.98.100
DTSTAMP:20250803T125535Z
DESCRIPTION:ºÚÁϲ»´òìÈ's Seminar Series in Quantitative Life Sciences and Medic
 ine\n	Sponsored by CAMBAM\, QLS\, MiCM and the Ludmer Centre\n	 \n\nTitle: M
 odeling axon-myelin relationships: insights on signal propagation and modu
 lation\n	Speaker: Claire Guerrier\, Université Côte d'Azur\n	When: Tuesday F
 ebruary 18\, 12-1pm\n	Where: Montreal Neurological Institute\, deGrandpre C
 ommunications Centre\n\n \n\nAbstract: The profound functional significanc
 e of myelin is revealed by the severe neurological deficits that are conse
 quent upon multiple inherited or acquired demyelinating conditions. Recent
  observations demonstrate that the dimensions of myelin sheaths relative t
 o axon calibres can be modulated in response to adult experience with sign
 ificant functional consequences. Despite the widely accepted demonstration
  that adult myelin is adaptive and the rapidly growing evidence that such 
 plasticity plays a key role in both normal and abnormal nervous system fun
 ction\, the effects of such myelin and axonal organization changes on sign
 al propagation are not clearly understood.\n	In this project\, using data o
 n myelin sheath thickness in relation to axonal diameter coming from gene 
 edited mice\, we investigate the effects of myelination on the propagation
  of electrical signals along these axons and vice versa. We consider an el
 ectrical model based on cable theory and on Holdgkin-Huxley type formalism
  to represent voltage gated channels at the nodes of Ranvier (NoR).\n	Using
  this model\, we investigate the effects of parameter sets corresponding t
 o pathological myelin-axon-NoR organisation\, on signal propagation. Using
  mathematical analysis and simulations\, we show that the different freque
 ncies constituting a signal travel at their own speed\, that depends on th
 e fibre properties. Although in normal axons and for a typical signal\, th
 e difference of speed for different frequencies is negligible\, in abnorma
 l demyelinated axons\, there are drastic differences\, which perturbs sign
 al propagation and modifies the shape of the outcoming signal.\n
DTSTART:20200218T170000Z
DTEND:20200218T180000Z
LOCATION:deGrandpre Communications Centre\, 3801 rue University\, Montreal\
 , QC\, H3A 2B4\, CA\, Montreal Neurological Institute\, CA\, QC\, Montreal
 \, H3A 2B4\, 3801 rue University
SUMMARY:Modeling axon-myelin relationships: insights on signal propagation 
 and modulation
URL:/micm/channels/event/modeling-axon-myelin-relation
 ships-insights-signal-propagation-and-modulation-320467
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