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UID:20250731T002652EDT-765974vLtz@132.216.98.100
DTSTAMP:20250731T042652Z
DESCRIPTION:\nGrâce à la générosité des fiducies Killam\, Le Neuro convoque
  lors d’une série de séminaires des conférenciers d’exception dont les tra
 vaux passionnent ses chercheurs et ceux de l’Université ºÚÁϲ»´òìÈ. \n\n\nPour
  assister en personne\, inscrivez-vous ici\n\nPour regarder via Vimeo\, cl
 iquez ici\n\n\nKevin Beier\n\nProfesseur associé\, Département de physiolo
 gie et de biophysique\, École de médecine\, Université de Californie\, Irv
 ine.\n\nHôte: wayne.sossin [at] mcgill.ca (Wayne Sossin)\n\nAbstract: Admi
 nistration of the Zeta Inhibitory Peptide (ZIP) interferes with memory mai
 ntenance and long-term potentiation (LTP). However\, mice lacking its puta
 tive target\, the protein kinase PKM2\, exhibit normal learning and memory
  as well as LTP\, making ZIP’s mechanism unclear. Here\, we show that ZIP 
 disrupts LTP by removing surface AMPA receptors through its cationic charg
 e alone. This effect requires endophilin A2 (endoA2)-mediated endocytosis 
 and is fully blocked by drugs suppressing macropinocytosis. ZIP and other 
 cationic peptides selectively remove newly inserted AMPAR nanoclusters\, p
 roviding a mechanism by which these peptides erase memories without alteri
 ng basal synaptic function. When delivered in vivo\, cationic peptides mod
 ulate memories on local and brain-wide scales and prevent memory loss in a
  model of traumatic brain injury. Our findings uncover a previously unknow
 n synaptic mechanism by which memories are maintained or lost.\n
DTSTART:20241022T200000Z
DTEND:20241022T210000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Think Positively: Novel Mechanisms of Modula
 ting Synaptic Plasticity and Implications for Brain Disease
URL:/neuro/fr/channels/event/killam-seminar-series-thi
 nk-positively-novel-mechanisms-modulating-synaptic-plasticity-and-358311
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