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UID:20250507T153929EDT-7344f4TTKe@132.216.98.100
DTSTAMP:20250507T193929Z
DESCRIPTION:La conférence Olszewski du Neuro\, créée en 1986\, rend hommage
  au Dr Jerzy Olszewski (1913–1964)\, un neuroanatomiste et neuropathologis
 te pionnier. Invité au Neuro par le Dr Wilder Penfield en 1948\, Olszewski
  a collaboré à l’ouvrage fondamental Cytoarchitecture of the Human Brain S
 tem\, contribuant à l’avancement de la compréhension des structures du tro
 nc cérébral et établissant son héritage dans le domaine des neurosciences.
 \n\n\nPour assister en personne\, inscrivez-vous ici\n\nPour regarder via 
 Vimeo\, cliquez ici\n\n\nXiaowei Zhuang \n\nHoward Hughes Medical Institut
 e\, Harvard University\n\nAbstract: Cell and tissue functions arise from t
 he coordinated activities of thousands of different genes. Understanding t
 hese functions requires imaging at the genome scale\, which advances knowl
 edge in many areas of biology\, from the regulation of gene expression in 
 cells to the development of cell fate and the organization of cell types i
 n complex tissues. A single-cell genome-scale imaging method\, multiplexed
  error-robust fluorescence in situ hybridization (MERFISH)\, was developed
  to enable spatially resolved single-cell transcriptomics\, epigenomics\, 
 3D-genomics\, and functional genomics. This method allows for single-cell 
 gene-expression profiling in intact tissues\, facilitating the identificat
 ion\, spatial mapping\, and functional investigation of distinct cell type
 s within those tissues. Using this approach\, molecularly defined\, spatia
 lly resolved\, and functionally annotated cell atlases of the brain have b
 een created. This lecture will describe the MERFISH technology and its app
 lications\, with a particular focus on mapping the molecular\, spatial\, a
 nd functional organizations of distinct cell types in the brain.\n
DTSTART:20250327T200000Z
DTEND:20250327T210000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Olszewski Lecture: Spatially Resolved Single-Cell Genomics & Cell A
 tlas of the Brain
URL:/neuro/fr/channels/event/olszewski-lecture-spatial
 ly-resolved-single-cell-genomics-cell-atlas-brain-361354
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