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UID:20250731T195101EDT-6192or4fD0@132.216.98.100
DTSTAMP:20250731T235101Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at the MNI and ºÚÁϲ»´òìÈ Universit
 y.\n\n\nTo attend in person\, register here\n\n\nJeehye Park\, PhD\n\nSeni
 or Scientist\, SickKids Research Institute\, Associate Professor\, Departm
 ent of Molecular Genetics\, University of Toronto\, Canada\n\nHost: gary.a
 rmstrong [at] mcgill.ca (Gary Armstrong)\n\nAbstract: Amyotrophic lateral 
 sclerosis (ALS) is a devastating neurodegenerative disease that leads to p
 rogressive decline in motor impairment\, muscle atrophy and paralysis. ALS
  studies provided significant insights into the disease process\, which ma
 y involve various molecular pathways and cellular dysfunction that contrib
 ute to neurodegeneration. However\, we still lack knowledge of how ALS sta
 rts to occur and develop\, particularly the mechanism underlying the early
  phase of the disease process. Understanding the early disease stage rathe
 r than the late disease stage would enhance our chance of developing effec
 tive treatments that could stop or reverse the disease course. To identify
  the disease-initiating events leading to degeneration\, we use our establ
 ished ALS mouse model\, MATR3 S85C knock-in (KI) mice. A missense mutation
  S85C is the most frequently identified ALS-linked mutation in MATR3\, whi
 ch encodes an RNA binding protein involved in RNA splicing. This newly est
 ablished ALS model closely mimics the human disease genotype and phenotype
 \, offering enhanced disease relevance compared to existing models in the 
 ALS field and providing an unprecedented opportunity to study the early-st
 age development and progression of ALS. Using this mouse model\, we pursue
  to 1) determine the early disease events in the disease process and 2) de
 termine how the ALS-linked mutation alters MATR3 function and properties t
 o cause neurodegeneration. Our findings will uncover the early disease pro
 cess\, which may change the view of how ALS develop and progress. Defining
  the key early events will facilitate the development of early prevention 
 and intervention strategies for ALS.\n
DTSTART:20240611T200000Z
DTEND:20240611T210000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Identifying the Early Events in ALS Pathogen
 esis in MATR3 S85C KI Mice
URL:/neuro/channels/event/killam-seminar-series-identi
 fying-early-events-als-pathogenesis-matr3-s85c-ki-mice-355311
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