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UID:20250801T022752EDT-6346jUZvu8@132.216.98.100
DTSTAMP:20250801T062752Z
DESCRIPTION:My research focus is on applying patient-derived stem cells tow
 ards the development of phenotypic discovery assays and 3D mini-brain mode
 ls for both neurodegenerative and neurodevelopmental disorders. As associa
 te director of the Early Drug Discovery Unit (EDDU) at the Montreal Neurol
 ogical Institute (MNI)\, I oversee a team of over 35 research staff and st
 udents\, committed to applying novel stem cell technology\, combined with 
 CRISPR genome editing\, mini-brain models and new microfluidic technologie
 s towards elucidating the underlying causes of these complex disorders. Co
 mbined with new approaches in the group towards building MultiOmics profil
 es on the patient-derived IPSC cells\, the long-term strategy is to identi
 fy new personalized precision therapies that can be applied towards buildi
 ng clinical trials on a dish. For todays talk\, I will discuss our 3D drug
  discovery pipeline\, in which we focus on translating findings from 2D ne
 urons\, into 3D brain organoids\, and ultimately into lead compounds. I wi
 ll present work on how we generate these cells\, the quality control proce
 ss and also some of the new technologies we are developing in the group fo
 r working with 3D neuronal organoids.\n\n \n
DTSTART:20191122T160000Z
DTEND:20191122T170000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Seminar - Modelling disorders of the brain through patient-derived 
 stem cells
URL:/physiology/channels/event/seminar-modelling-disor
 ders-brain-through-patient-derived-stem-cells-300014
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