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UID:20250805T235508EDT-7881gxt08p@132.216.98.100
DTSTAMP:20250806T035508Z
DESCRIPTION:This seminar has been cancelled.\n\nInvasive fungal disease (IF
 D) is estimated to cause more deaths than either tuberculosis or malaria. 
 The ubiquitous soil-associated fungus Cryptococcus neoformans is the leadi
 ng cause of mortality due to IFD. Infection with C. neoformans begins with
  pneumonia and may progress to life-threatening meningitis. C. neoformans 
 infects a wide spectrum of patients ranging from apparently healthy indivi
 duals to those with defective immunity\, yet the determinants of which exp
 osed individuals will ultimately develop disease are poorly understood. Fu
 rthermore\, among individuals with established C. neoformans disease there
  is broad variation in clinical progression and responses to therapy. Inbr
 ed mouse strains also exhibit significant differences in host resistance a
 gainst experimental pulmonary infection with C. neoformans. Using forward 
 genetic analysis and construction of congenic/sub-congenic mouse strains\,
  we have identified and validated the biological role of two susceptibilit
 y loci that regulate the host response to C. neoformans pneumonia. We aim 
 to identify candidate genes that underlie the differential resistance phen
 otype using immune profiling in the lung in combination with comparative s
 equence and expression analysis of effector cell populations. Our overall 
 research aim is to discover the mechanisms that regulate permissive versus
  protective host responses and use this knowledge to identify prognostic b
 iomarkers and ultimately to develop personalized therapeutics to promote d
 urable and appropriately regulated protective immunity.\n
DTSTART:20200403T150000Z
DTEND:20200403T160000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:SEMINAR CANCELLED
URL:/physiology/channels/event/seminar-cancelled-32105
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