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UID:20250708T213007EDT-858756F8P5@132.216.98.100
DTSTAMP:20250709T013007Z
DESCRIPTION:\n	In 1947 Heilbrunn & Wiercinski established that calcium was t
 he ion that triggered contraction in muscle. Efforts to measure calcium in
  the cardiovascular system have continuously been developed since then in 
 healthy and diseased states [reviewed in Broyles et al\, 2018\, PMID 29857
 560]\n\nWe are interested in the changes in intracellular calcium that occ
 ur in a common inherited cardiac condition called hypertrophic cardiomyopa
 thy\, that affects about 1:250-500 people and is a leading cause of sudden
  death in apparently well\, young\, adults. Both contractility\, and calci
 um are abnormal in this condition\, but there are clear discrepancies betw
 een the two measurements - contracility measurements are abnormal througho
 ut the contractile cycle\; calcium measurements are apparently only abnorm
 al during diastole.\n\nIn unpublished work that I will discuss we are able
  to reconcile this observation\, and overcome the problem of calcium and c
 ontractile measurement using genetically encoded calcium indicators that w
 e are able to bury into the sarcomere adjacent to where we know the mutati
 ons that cause hypertrophic cardiomyopathy are found [Sparrow et al\, 2019
 \, PMID 30732532\; Sparrow et al 2020\, PMID 32083971]\n\nI will discuss s
 ome modifications that allow us to measure calcium and contractility simul
 taneously in the single IPS-CM model.\n\nThis seminar will be given online
  via Zoom. Details in attached poster.\n
DTSTART:20200605T150000Z
DTEND:20200605T160000Z
SUMMARY:Online Seminar - Calcium imaging in cardiomyocytes in general\, and
  hypertrophic cardiomyopathy in particular
URL:/physiology/channels/event/online-seminar-calcium-
 imaging-cardiomyocytes-general-and-hypertrophic-cardiomyopathy-particular-
 322327
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