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UID:20250830T061248EDT-33516l8Lnm@132.216.98.100
DTSTAMP:20250830T101248Z
DESCRIPTION:The supraoptic (SON) and paraventricular (PVN) nuclei of the hy
 pothalamus play critical roles in the regulation of bodily homeostasis\, i
 ncluding the generation of coordinated neurosecretory and autonomic respon
 ses during challenges to fluid and electrolyte balance. In addition to maj
 or output neurons\, including vasopressinergic (VP) and oxytocinergic (OT)
  magnocellular neurons\, the SON and PVN also harbor a rich network of ast
 roglial cells\, and are some of the most vascularized regions in the brain
 . Still\, a detailed characterization of the neurovascular unit within nuc
 lei\, and the functional significance of this uniquely rich vascularizatio
 n remains puzzling.\n\nThe classical model of neurovascular coupling (NVC)
  implies that activity-dependent axonal glutamate release at synapses evok
 es the production and release of vasoactive signals from both neurons and 
 astrocytes\, which dilate arterioles\, increasing in turn cerebral blood f
 low (CBF) to areas with increased metabolic needs. One limitation in the f
 ield is than In vivo imaging of neurovascular coupling has largely been li
 mited to superficial brain areas\, which has led to the conventional view 
 that this modality of NVC is common to all brain regions. However\, whethe
 r this model is also applicable to brain areas that also use less conventi
 onal neurotransmitters\, such as neuropeptides\, and which generally proce
 ss information at a very different spatio-temporal scale\, is currently un
 known. \n\nTo start addressing some of these critical gaps in the field\, 
 we developed a surgical approach to allow in vivo two-photon imaging from 
 the ventral surface of the brain. Using this approach\, we aimed to measur
 e NVC the SON in response to a systemic homeostatic challenge. Using a tra
 nsgenic rat expressing eGFP driven by the vasopressin promoter\, in conjun
 ction with the delivery of intravascular fluorescent dyes\, we were able t
 o successfully image SON neurons and the local microvasculature in vivo in
  anesthetized rats. During my presentation\, I will summarize the results 
 obtained thus far using this novel approach\, which overall support the pr
 esence of an unconventional NVC modality in the SON evoked by activity-dep
 endent\, local dendritic release of VP. Furthermore\, I will discuss the p
 otential functional implication for this form of NVC within the context of
  fluid/electrolyte homeostasis.\n\nThis seminar will be given online via Z
 oom. See attached poster for details.\n
DTSTART:20201023T150000Z
DTEND:20201023T160000Z
SUMMARY:Online Seminar: Unconventional neurovascular coupling modality in t
 he hypothalamus in response to a systemic homeostatic challenge
URL:/physiology/channels/event/online-seminar-unconven
 tional-neurovascular-coupling-modality-hypothalamus-response-systemic-3249
 94
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