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UID:20250731T193911EDT-9225WrFPwa@132.216.98.100
DTSTAMP:20250731T233911Z
DESCRIPTION:Over the last 2 decades\, the nematode C. elegans has become an
  important model for the study of host-pathogen interactions. It deploys a
  wide range of strategies to defend itself against infection. The first is
  pathogen evasion. Through chemosensation\, C. elegans is able to detect s
 pecific microbial products\, such as surfactants and quorum sensing molecu
 les\, and has the capacity to learn to avoid particular pathogens. If C. e
 legans is infected\, this generally triggers the expression of defence pro
 grammes\, involving the transcriptional up-regulation of hundreds of genes
 \, with profound effects on physiology.\n\nLately\, we have focused our st
 udies on the epidermal innate response to a natural fungal pathogen. We ha
 ve combined genetics\, functional genomics\, biochemistry and cell biology
  to build up a picture of the complex cross-talk between multiple cellular
  homeostatic processes and cellular stress that underlies anti-fungal inna
 te immunity. In addition to cell-autonomous defences\, the immune response
  involves reciprocal communication with the nervous system\, with an impac
 t on development\, sleep and neurodegeneration. In parallel\, we have begu
 n to explore the basis of fungal virulence and uncovered a remarkable vari
 ety of strategies that contribute to pathogenesis and fungal manipulation 
 of host physiology.\n\nThis seminar will be given online via Zoom. Details
  in attached poster.\n
DTSTART:20201127T160000Z
DTEND:20201127T170000Z
SUMMARY:Online Seminar - Resist or die: host-pathogen interactions in C. el
 egans
URL:/physiology/channels/event/online-seminar-resist-o
 r-die-host-pathogen-interactions-c-elegans-325179
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