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UID:20250818T232604EDT-8717lrrjV3@132.216.98.100
DTSTAMP:20250819T032604Z
DESCRIPTION:Maintaining average activity level within a set-point range con
 stitutes a fundamental property of central neural circuits. Accumulated ev
 idence suggests that mean firing rate (MFR)\, reflecting an average level 
 of spontaneous spiking activity over extended timescales\, represents a ph
 ysiological variable regulated by homeostatic systems in central neural ci
 rcuits. However\, some central questions have remained open. What are the 
 mechanisms that establish the specific values of MFR set-points? Are MFR s
 et-points fixed (predetermined) or adjustable in central neural circuits? 
 If they are adjustable\, do separate mechanisms control negative feedback 
 responses and MFR set-point value? And finally\, whether re-adjustment of 
 dysregulated firing set-points may provide a new conceptual way to treat b
 rain disorders associated with aberrant network activity? I will present o
 ur new approach\, integrating genome-scale metabolic modeling and experime
 ntal study of neuronal homeostasis\, to predict homeostatic regulators in 
 specific neural circuits. Next\, I will show our new results on the role o
 f mitochondrial signaling in the regulation of activity set-points in hipp
 ocampal circuits ex vivo and in vivo. Finally\, I will provide the evidenc
 e for a new potential strategy to suppress seizures by lowering firing set
 -points.\n\nThis seminar will be given online via Zoom. Details in attache
 d poster.\n\n \n
DTSTART:20211015T150000Z
DTEND:20211015T160000Z
SUMMARY:Online seminar: Regulation and dysregulation of activity set-point 
 in hippocampal circuits
URL:/physiology/channels/event/online-seminar-regulati
 on-and-dysregulation-activity-set-point-hippocampal-circuits-325369
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