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UID:20250801T041043EDT-95692m2W8X@132.216.98.100
DTSTAMP:20250801T081043Z
DESCRIPTION:In this seminar\, I will present our ongoing research in the re
 gulation of expression of Heat Shock Proteins (HSPs) in neurons undergoing
  pathophysiological stresses and their relation to age-related neurodegene
 rative diseases. HSPs are molecular chaperones in charge of protein foldin
 g and homeostasis. Cells have the remarkable capacity to tailor the expres
 sion of HSPs to the extent of protein damage. The precise regulation of HS
 P expression is required to safeguard protein homeostasis and ensure cell 
 functionality upon proteotoxic damage. Using single-molecule fluorescence 
 microscopy techniques\, we have discovered that beyond the activation of H
 SP transcription\, neurons regulate the subcellular distribution of HSP mR
 NAs in response to stress. mRNA localization to neuronal projections emerg
 es as a novel mechanism to regulate the local pool of HSPs and sustain pro
 teostasis at neuronal processes. As I share our advancements on this proje
 ct\, I will introduce several mRNA imaging technologies that are helping u
 s to answer fundamental gene expression regulation questions.\n\nThis semi
 nar will be given online via Zoom. Details in attached poster.\n
DTSTART:20220211T160000Z
DTEND:20220211T170000Z
SUMMARY:Online seminar: Imaging single mRNA molecules to investigate neuron
 al protein homeostasis
URL:/physiology/channels/event/online-seminar-imaging-
 single-mrna-molecules-investigate-neuronal-protein-homeostasis-337222
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