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UID:20250819T105556EDT-7843RA8cjM@132.216.98.100
DTSTAMP:20250819T145556Z
DESCRIPTION:Integrin-based focal and fibrillar cell-extracellular matrix ad
 hesions (FA and Fib) are critical for the matrix rigidity sensing and fibr
 onectin fibrillogenesis\, respectively. Besides the association with the a
 ctin cytoskeleton\, they interact with microtubules through molecular comp
 lexes containing KANK family proteins. Here\, we compare the mechanisms un
 derlying the FA and Fib dynamics. Microtubule disassembly or uncoupling fr
 om the adhesions by disruption of KANK-mediated link results in augmentati
 on of FA but elimination of Fib. Thus\, microtubules negatively regulate F
 A and positively - Fib. The underlying mechanism in both cases is a releas
 e from adhesion-uncoupled microtubules of Rho activator GEF-H1\, triggerin
 g Rho-ROCK-myosin-II signaling cascade. Consequent burst of actomyosin con
 tractility promotes the growth of mechanosensory FA and the disassembly of
  Fib. The same mechanism\, local GEF-H1-dependent myosin-II activation\, i
 s involved in the sliding and disruption of the individual FA upon microtu
 bule targeting to FA by optogenetic activation of KANK1. Thus\, microtubul
 es function as sensory and regulatory elements\, whose interactions with i
 ntegrin adhesions locally control formation of myosin filaments\, which in
  turn remodel adhesions. While both FA and Fib can be formed by cells on p
 lanar substrate\, Fib formation is specifically activated (in a myosin-II 
 independent manner) by physiologically relevant micropatterns – decellular
 ized extracellular matrix\, electrospun nanofibers\, or edges of microfabr
 icated ridges. Consistently\, the treatments increasing membrane/cortical 
 tension disassemble fibrillar adhesions\, but not focal adhesions. Thus\, 
 selective sensitivity of fibrillar adhesions to microtubule uncoupling and
  subsequent local myosin II activation can be explained by the myosin II-d
 riven increase of membrane/cortical tension.\n\nThis seminar will take pla
 ce in -person and online (details in attached poster below).  All are welc
 ome!\n\n \n
DTSTART:20230918T150000Z
DTEND:20230918T160000Z
LOCATION:208/209\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y6
 \, 3655 promenade Sir William Osler
SUMMARY:Physiology Seminar: Dr. Alexander Bershadsky:' Integrin-mediated ad
 hesions in a crosstalk with actomyosin cytoskeleton and microtubules'
URL:/physiology/channels/event/physiology-seminar-dr-a
 lexander-bershadsky-integrin-mediated-adhesions-crosstalk-actomyosin-35067
 1
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