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UID:20250801T165940EDT-3123ijzTPF@132.216.98.100
DTSTAMP:20250801T205940Z
DESCRIPTION:How do noncoding risk variants contribute to complex traits and
  diseases?\n\nBing Ren\, UC San Diego\n	Tuesday December 15\, 12-1pm\n	Zoom 
 Link: https:/mcgill.zoom.us/j/91589192037\n\nAbstract: A large number of s
 equence variants have been linked to complex traits and disease through ge
 nome-wide association studies\, but deciphering their biological function 
 is still challenging because most of them reside in noncoding DNA\, where 
 functional annotation is still lacking. A growing list of studies has show
 n that noncoding risk variants may contribute to human disease by perturbi
 ng the transcriptional regulatory sequences. However\, it is still unclear
  whether this mechanism generally applies to the tens of thousands of risk
  variants identified to date. Efforts to address this question have been h
 ampered by a lack of maps and tools to explore the transcriptional regulat
 ory sequences in the human genome. Here\, I will present our recent progre
 ss in the mapping of candidate transcriptional regulatory sequences in the
  human and mouse genomes with single cell epigenomics tools. I will also d
 iscuss the development of highly predictive models for assessing the impac
 t of sequence variants on DNA binding of transcription factors. Finally\, 
 I will describe how mapping the long-range chromatin interactions allows u
 s to infer the target genes of noncoding risk variants in common diseases.
 \n
DTSTART:20201215T170000Z
DTEND:20201215T180000Z
LOCATION:CA\, QC
SUMMARY:QLS Seminar Series - Bing Ren
URL:/qls/channels/event/qls-seminar-series-bing-ren-32
 6550
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